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Saikosaponin A

CAS No. 20736-09-8

Saikosaponin A( Saikosaponin A )

Catalog No. M13225 CAS No. 20736-09-8

Extracted from Bupleurum,scorzonerifolium;Suitability:Water,dilute alcohol,especially the hot water,hot alcohol,butanol and pentanol;Store the product in sealed,cool and dry condition

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Saikosaponin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Extracted from Bupleurum,scorzonerifolium;Suitability:Water,dilute alcohol,especially the hot water,hot alcohol,butanol and pentanol;Store the product in sealed,cool and dry condition
  • Description
    Extracted from Bupleurum,scorzonerifolium;Suitability:Water,dilute alcohol,especially the hot water,hot alcohol,butanol and pentanol;Store the product in sealed,cool and dry condition.
  • In Vitro
    Western Blot Analysis Cell Line:Human osteoarthritis chondrocytes Concentration:5, 10, 15 μM Incubation Time:24 h Result:Inhibited the levels of phosphorylation of NF-κB p65 and IκBα induced byIL-1β.Up-regulated the expression of LXRα in a dose-dependent manner.
  • In Vivo
    Animal Model:5-FU (HY-90006)-induced mucositis in BALB/c mice modle Dosage:1, 5, 10?mg/kg/day, 7 d Administration:injected intraperitoneally (i.p)Result:Reduced villus blunting, crypt cells apoptosis, and inflammatory cell infiltration.Decreased concentration of GSH, GST, Catalase, and SOD in intestinal tissue.
  • Synonyms
    Saikosaponin A
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    20736-09-8
  • Formula Weight
    780.99
  • Molecular Formula
    C42H68O13
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    O[C@H]([C@H]([C@@H]([C@@H](C)O1)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@H]1OC3CC[C@]4(C)[C@@]5([H])C=C[C@]67[C@]8([H])CC(C)(C)CC[C@@](CO7)8[C@H](O)C[C@](C)6[C@@](C)5CC[C@]([H])4[C@]3(C)CO
  • Chemical Name
    (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-3,5-dihydroxy-2-(((4R,4aR,6aR,6bS,8R,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-2,3,4,4a,5,6,6a,6b,7,8,10,11,12,12a,14a,14b-hexadecahydro-1H,9H-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhao H, et al. Exp Ther Med. 2015 Aug;10(2):823-827.
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